Elliott B Grossbard Selected Research

fostamatinib

7/2013	Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies.
4/2013	Effects of fostamatinib (R788), an oral spleen tyrosine kinase inhibitor, on health-related quality of life in patients with active rheumatoid arthritis: analyses of patient-reported outcomes from a randomized, double-blind, placebo-controlled trial.
9/2011	Fostamatinib, a Syk-kinase inhibitor, does not affect methotrexate pharmacokinetics in patients with rheumatoid arthritis.
2/2011	An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents.

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Elliott B Grossbard Research Topics

Disease

8	Rheumatoid Arthritis 07/2013 - 07/2004
2	Synovitis 02/2011 - 09/2007
2	Arthritis (Polyarthritis) 08/2009 - 12/2006
2	Autoimmune Diseases (Autoimmune Disease) 09/2007 - 07/2004
1	Fatigue 04/2013
1	Pain (Aches) 04/2013
1	Hereditary renal agenesis 02/2009
1	Azotemia 05/2008
1	Proteinuria 05/2008
1	Disease Progression 05/2008
1	Arthus Reaction 12/2006
1	Inflammation (Inflammations) 12/2006
1	Seasonal Allergic Rhinitis (Hay Fever) 04/2005
1	Crohn Disease (Crohn's Disease) 07/2004

Drug/Important Bio-Agent (IBA)

9	Syk KinaseIBA 07/2013 - 04/2005
4	fostamatinibIBA 07/2013 - 02/2011
3	Methotrexate (Mexate)FDA LinkGeneric 04/2013 - 09/2010
2	Fc Receptors (Fc Receptor)IBA 12/2006 - 07/2004
1	ProdrugsIBA 07/2013
1	SteroidsIBA 02/2011
1	Biological ProductsIBA 02/2011
1	C-Reactive ProteinIBA 02/2011
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2009
1	AutoantibodiesIBA 05/2008
1	NitrogenIBA 05/2008
1	Urea (Carbamide)FDA LinkGeneric 05/2008
1	Antirheumatic Agents (DMARD)IBA 09/2007
1	Antigen-Antibody Complex (Immune Complex)IBA 12/2006
1	AntibodiesIBA 12/2006
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2004
1	Monoclonal AntibodiesIBA 07/2004
1	anti-IgE antibodiesIBA 07/2004

Therapy/Procedure

2	Therapeutics 09/2011 - 09/2010
1	Biological Therapy 02/2011
1	Oral Administration 12/2006